desvenlafaxine will boost the amount or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment needed with desvenlafaxine doses 7 consecutive days quickly … Read More